Tools for mapping high-throughput sequencing data

Tools for mapping high-throughput sequencing data

MOTIVATION A ubiquitous and fundamental step in high-throughput sequencing analysis is the alignment (mapping) of the generated reads to a reference sequence. To accomplish this task, numerous software tools have been proposed. Determining the mappers that are most suitable for a specific application is not trivial. RESULTS This survey focuses on classifying mappers through a wide number of c...

Data Analysis Tools and Methods for Dna Microarray and High-throughput Sequencing Data

Algorithms and tools for the analysis of high throughput DNA sequencing data

High-throughput DNA sequencing technologies make it possible to determine the order of the nucleotides adenine, cytosine, guanine and thymine in DNA samples, resulting in millions of short strings (reads) over the alphabet (A, C, G, T). Advances in biological and biomedical research rely on the ability of bioinformatics to make sense out of that data with novel algorithms and tools. In this the...

TriageTools: tools for partitioning and prioritizing analysis of high-throughput sequencing data

High-throughput sequencing is becoming a popular research tool but carries with it considerable costs in terms of computation time, data storage and bandwidth. Meanwhile, some research applications focusing on individual genes or pathways do not necessitate processing of a full sequencing dataset. Thus, it is desirable to partition a large dataset into smaller, manageable, but relevant pieces. ...

Sequencing quality assessment tools to enable data-driven informatics for high throughput genomics

The processes of quality assessment and control are an active area of research at The Genome Analysis Centre (TGAC). Unlike other sequencing centers that often concentrate on a certain species or technology, TGAC applies expertise in genomics and bioinformatics to a wide range of projects, often requiring bespoke wet lab and in silico workflows. TGAC is fortunate to have access to a diverse ran...